Antiproliferative Oleanane Saponins from Meryta denhamii

Authors :: Fabrizio Dal Piaz
Francesco De Simone
Giuseppina Cioffi
Antonio Vassallo
Nunziatina De Tommasi
Fabio Venturella
Paolo De Caprariis
CIOFFI, G
DAL PIAZ, F
VASSALLO, A
VENTURELLA, F
DE CAPRARIIS, P
DE SIMONE, F
DE TOMMASI, N
Source :: Journal of Natural Products. 71:1000-1004
Publication Year :: 2008
Publisher :: American Chemical Society (ACS), 2008.
Abstract: Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.