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Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy
- Source :
- Herz. 42:669-676
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p
- Subjects :
- Adult
Cardiomyopathy, Dilated
Male
medicine.medical_specialty
Adolescent
Heart Ventricles
Population
030204 cardiovascular system & hematology
Ventricular Dysfunction, Left
Young Adult
03 medical and health sciences
0302 clinical medicine
Reference Values
Internal medicine
Idiopathic dilated cardiomyopathy
medicine
Humans
Circumferential strain
Genetic Testing
030212 general & internal medicine
First-degree relatives
education
Subclinical infection
Body surface area
education.field_of_study
Ejection fraction
business.industry
Dilated cardiomyopathy
Middle Aged
medicine.disease
Echocardiography
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 16156692 and 03409937
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Herz
- Accession number :
- edsair.doi.dedup.....331857723148b24e864b8d814ee9366a