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Lansoprazole increases serum IgG and IgM in H. pylori-infected patients
- Source :
- International journal of immunopathology and pharmacology. 20(1)
- Publication Year :
- 2007
-
Abstract
- Proton-pump inhibitors have been reported to influence the human immune system, we therefore evaluated the effect of lansoprazole, a proton-pump inhibitor, on humoral immunity. Patients with gastric ulcer received lansoprazole 30 mg/day for 8 weeks, and serum immunoglobulins were evaluated before and upon completion of the treatment. There were 79 patients with gastric ulcer; 51 were H. pylori-infected and 28 were H. pylori-uninfected. Eighteen patients positive for H. pylori were receiving at least one non-steroidal anti-inflammatory drug, and 12 patients negative for H. pylori received one non-steroidal anti-inflammatory drug. H. pylori-infected patients showed significant increases in serum immunoglobulins G and M 8 weeks after the start of lansoprazole treatment ( P
- Subjects :
- Drug
Male
medicine.medical_specialty
media_common.quotation_subject
Immunology
Lansoprazole
Gastroenterology
2-Pyridinylmethylsulfinylbenzimidazoles
Helicobacter Infections
Elevated serum
03 medical and health sciences
0302 clinical medicine
Immune system
Internal medicine
Immunology and Allergy
Medicine
Humans
Drug Interactions
Stomach Ulcer
Enzyme Inhibitors
media_common
Aged
Pharmacology
Aspirin
biology
Helicobacter pylori
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Proton Pump Inhibitors
Middle Aged
biology.organism_classification
Immunoglobulin A
Immunoglobulin M
030220 oncology & carcinogenesis
Immunoglobulin G
Humoral immunity
Antibody Formation
biology.protein
Female
Antibody
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 03946320
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of immunopathology and pharmacology
- Accession number :
- edsair.doi.dedup.....3315e0970e87ad605dfbb3a0108604c7