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Sodium orthovanadate inhibits growth of acute leukemia HL60 cells and HL60/A cells in vitro
- Source :
- Bioscience Reports
- Publication Year :
- 2020
- Publisher :
- Portland Press Ltd., 2020.
-
Abstract
- Vanadium is an ultratrace element. The transition metal vanadium, widely exists in the environment and exhibits various biological and physiological effects in the human body, yet with no presently known specific physiological function in mammals. Sodium orthovanadate (SOV) is a kind of vanadium compound. SOV has shown promising antineoplastic activity in several human cancers. But the effects of SOV on acute promyelocytic leukemia (APL) are still unknown. In the present study, for the first time, we found that SOV could inhibit proliferation, induce G2/M cell cycle arrest and apoptosis, and could inhibit autophagy of acute leukemia cell lines in vitro. Thus, our findings suggest that SOV could effectively suppress the growth of acute leukemia HL60 cells and HL60/A cells through the regulations of proliferation, cell cycle, apoptosis and autophagy, and thus may act as a potential therapeutic agent in APL treatment.
- Subjects :
- Acute promyelocytic leukemia
HL60
Biophysics
Antineoplastic Agents
Apoptosis
HL-60 Cells
Biochemistry
chemistry.chemical_compound
Leukemia, Promyelocytic, Acute
Autophagy
medicine
Humans
Molecular Biology
Sodium orthovanadate
Research Articles
Cell Proliferation
Cancer
Acute leukemia
Cell Biology
Cell cycle
medicine.disease
G2 Phase Cell Cycle Checkpoints
chemistry
Cell culture
Cell Cycle, Growth & Proliferation
Cancer research
Drug Screening Assays, Antitumor
Vanadates
Subjects
Details
- ISSN :
- 15734935 and 01448463
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....330d814a5f3dea93dd280a195f400f43