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Autonomic dysfunction with early respiratory syncytial virus-related infection
- Source :
- Autonomic neuroscience : basicclinical. 156(1-2)
- Publication Year :
- 2009
-
Abstract
- Background Apparent life-threatening events (ALTE) and/or prolonged apnoea have been well-documented during respiratory syncytial virus (RSV) infection in infants less than 2 months of age but fundamental mechanisms remain unclear. The possibility of a central origin for the development of severe cardiac and respiratory events encouraged us, to explore the autonomic nervous system (ANS) profile of infected infants, since ANS activity may contribute to the constellation of symptoms observed during severe forms of RSV bronchiolitis. Methods Eight infants (2 preterm and 6 full-term) less than 2 months of age and presenting with severe and apnoeic forms of RSV infection were evaluated using non-invasive electrophysiological monitoring obtained simultaneously for approximately 2 consecutive hours, including a quiet sleep period. Eight control subjects, paired for gestational and postnatal age, were also evaluated. ANS status was monitored using electrocardiogram recordings and quantified through a frequency-domain analysis of heart rate variability (HRV). This included sympathetic (VLF and LF) and parasympathetic (HF) indices as well as a measure of baroreflex sensitivity (BRS) obtained using non-invasive continuous arterial pressure. Results Regardless of gestational and postnatal age, heart rate variability components (Ptot, VLF, LF, and HF) and baroreflex components (α LF, α HF and sBR) were found to be significantly lower in the RSV-infected group than in the control group ( p Conclusion RSV infection in neonates is associated with profound central autonomic dysfunction. The potentially fatal consequence stresses the importance of maintaining prolonged cardiopulmonary monitoring.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Respiratory Syncytial Virus Infections
Baroreflex
Autonomic Nervous System
Cellular and Molecular Neuroscience
Young Adult
Heart Rate
Internal medicine
Heart rate
Heart rate variability
Medicine
Humans
Respiratory system
Endocrine and Autonomic Systems
business.industry
Age Factors
Infant, Newborn
medicine.disease
Respiratory Syncytial Viruses
Virus Latency
Autonomic nervous system
Postnatal age
Blood pressure
Bronchiolitis
Anesthesia
Cardiology
Female
Neurology (clinical)
business
Sleep
Infant, Premature
Subjects
Details
- ISSN :
- 18727484
- Volume :
- 156
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Autonomic neuroscience : basicclinical
- Accession number :
- edsair.doi.dedup.....330cb69e717243e0bd5b0eea60a1c398