Defects of lipoprotein metabolism in familial combined hyperlipidaemia

Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the different metabolic pathways contributing to the pathogenesis of familial combined hyperlipidaemia. Curr Opin Lipidol 9:189–196. © 1998 Lippincott–Raven Publishers