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Risk factor burden, heart failure, and survival in women of different ethnic groups insights from the women's health initiative
- Source :
- Circulation. Heart failure, vol 11, iss 5, Breathett, K; Leng, I; Foraker, RE; Abraham, WT; Coker, L; Whitfield, KE; et al.(2018). Risk factor burden, heart failure, and survival in women of different ethnic groups insights from the women's health initiative. Circulation: Heart Failure, 11(5), e004642. doi: 10.1161/CIRCHEARTFAILURE.117.004642. UCSF: Retrieved from: http://www.escholarship.org/uc/item/997787r3
- Publication Year :
- 2018
- Publisher :
- Lippincott Williams and Wilkins, 2018.
-
Abstract
- Background: The higher risk of heart failure (HF) in African-American and Hispanic women compared with white women is related to the higher burden of risk factors (RFs) in minorities. However, it is unclear if there are differences in the association between the number of RFs for HF and the risk of development of HF and death within racial/ethnic groups. Methods and Results: In the WHI (Women’s Health Initiative; 1993–2010), African-American (n=11 996), white (n=18 479), and Hispanic (n=5096) women with 1, 2, or 3+ baseline RFs were compared with women with 0 RF within their respective racial/ethnic groups to assess risk of developing HF or all-cause mortality before and after HF, using survival analyses. After adjusting for age, socioeconomic status, and hormone therapy, the subdistribution hazard ratio (95% confidence interval) of developing HF increased as number of RFs increased ( P P =0.18)—African-Americans 1 RF: 1.80 (1.01–3.20), 2 RFs: 3.19 (1.84–5.54), 3+ RFs: 7.31 (4.26–12.56); Whites 1 RF: 1.27 (1.04–1.54), 2 RFs: 1.95 (1.60–2.36), 3+ RFs: 4.07 (3.36–4.93); Hispanics 1 RF: 1.72 (0.68–4.34), 2 RFs: 3.87 (1.60–9.37), 3+ RFs: 8.80 (3.62–21.42). Risk of death before developing HF increased with subsequent RFs ( P P =0.001). The number of RFs was not associated with the risk of death after developing HF in any group ( P =0.25; interaction P =0.48). Conclusions: Among diverse racial/ethnic groups, an increase in the number of baseline RFs was associated with higher risk of HF and death before HF but was not associated with death after HF. Early RF prevention may reduce the burden of HF across multiple racial/ethnic groups.
- Subjects :
- genetic structures
Medical Physiology
Ethnic group
030204 cardiovascular system & hematology
Cardiorespiratory Medicine and Haematology
Cardiovascular
ethnic groups
survival
Article
03 medical and health sciences
0302 clinical medicine
Clinical Research
Risk Factors
medicine
Ethnicity
Humans
030212 general & internal medicine
Risk factor
skin and connective tissue diseases
Socioeconomic status
Survival analysis
Aged
Proportional Hazards Models
African Americans
Heart Failure
Continental Population Groups
Proportional hazards model
business.industry
Women's Health Initiative
Prevention
Racial Groups
Middle Aged
medicine.disease
Survival Analysis
Confidence interval
Black or African American
Heart Disease
Cardiovascular System & Hematology
Heart failure
Women's Health
Female
women
Biochemistry and Cell Biology
Cardiology and Cardiovascular Medicine
business
Demography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Circulation. Heart failure, vol 11, iss 5, Breathett, K; Leng, I; Foraker, RE; Abraham, WT; Coker, L; Whitfield, KE; et al.(2018). Risk factor burden, heart failure, and survival in women of different ethnic groups insights from the women's health initiative. Circulation: Heart Failure, 11(5), e004642. doi: 10.1161/CIRCHEARTFAILURE.117.004642. UCSF: Retrieved from: http://www.escholarship.org/uc/item/997787r3
- Accession number :
- edsair.doi.dedup.....330a96f65e487e2056ec794d0e17b42b
- Full Text :
- https://doi.org/10.17615/2xnf-gz58