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Peptide-Based Vaccination Therapy for Rheumatic Diseases
- Source :
- Journal of Immunology Research, Vol 2020 (2020), Journal of Immunology Research
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Rheumatic diseases are extremely heterogeneous diseases with substantial risks of morbidity and mortality, and there is a pressing need in developing more safe and cost-effective treatment strategies. Peptide-based vaccination is a highly desirable strategy in treating noninfection diseases, such as cancer and autoimmune diseases, and has gained increasing attentions. This review is aimed at providing a brief overview of the recent advances in peptide-based vaccination therapy for rheumatic diseases. Tremendous efforts have been made to develop effective peptide-based vaccinations against rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), while studies in other rheumatic diseases are still limited. Peptide-based active vaccination against pathogenic cytokines such as TNF-α and interferon-α (IFN-α) is shown to be promising in treating RA or SLE. Moreover, peptide-based tolerogenic vaccinations also have encouraging results in treating RA or SLE. However, most studies available now have been mainly based on animal models, while evidence from clinical studies is still lacking. The translation of these advances from experimental studies into clinical therapy remains impeded by some obstacles such as species difference in immunity, disease heterogeneity, and lack of safe delivery carriers or adjuvants. Nevertheless, advances in high-throughput technology, bioinformatics, and nanotechnology may help overcome these impediments and facilitate the successful development of peptide-based vaccination therapy for rheumatic diseases.
- Subjects :
- medicine.medical_specialty
Immunology
Review Article
Disease
03 medical and health sciences
0302 clinical medicine
Immunity
Rheumatic Diseases
Immune Tolerance
medicine
Animals
Humans
Immunology and Allergy
Intensive care medicine
030304 developmental biology
030203 arthritis & rheumatology
0303 health sciences
business.industry
Vaccination
Cancer
General Medicine
Safe delivery
RC581-607
medicine.disease
Disease Models, Animal
Clinical therapy
Rheumatoid arthritis
Vaccines, Subunit
Treatment strategy
Immunologic diseases. Allergy
business
Subjects
Details
- Language :
- English
- ISSN :
- 23147156 and 23148861
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....33078ba99ab75b6deb932d23ae24a248