The neuroprotective effects of carnosine in early stage of focal ischemia rodent model

OBJECTIVE This study was conducted to elucidate neuroprotective effect of carnosine in early stage of stroke. METHODS Early stage of rodent stroke model and neuroblastoma chemical hypoxia model was established by middle cerebral artery occlusion and antimycin A. Neuroprotective effect of carnosine was investigated with 100, 250, and 500 mg of carnosine treatment. And antioxidant expression was analyzed by enzyme linked immunosorbent assay (ELISA) and western blot in brain and blood. RESULTS Intraperitoneal injection of 500 mg carnosine induced significant decrease of infarct volume and expansion of penumbra (p