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Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity
Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity
- Source :
- Natural product reports. 36(5)
- Publication Year :
- 2018
-
Abstract
- Covering: 1957 to 2017 Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment. Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment. Because of their structural diversity and uniqueness, these molecules have recently gained a lot of interest for the identification of medicinally useful agents, including those with potential anticancer activities. In the current review, which is not a catalogue-based one, we first highlight the major biological events that lead to various types of cancer, including metastatic ones, to chemoresistance, thus to any types of current anticancer treatment relating to the use of chemotherapeutics. We then review algal metabolites for which scientific literature reports anticancer activity. Lastly, we focus on algal metabolites with promising anticancer activity based on their ability to target biological characteristics of cancer cells responsible for poor treatment outcomes. Thus, we highlight compounds that have, among others, one or more of the following characteristics: selectivity in reducing the proliferation of cancer cells over normal ones, potential for killing cancer cells through non-apoptotic signaling pathways, ability to circumvent MDR-related efflux pumps, and activity in vivo in relevant pre-clinical models.
- Subjects :
- Drug Evaluation, Preclinical
Antineoplastic Agents
Apoptosis
010402 general chemistry
Inhibitory postsynaptic potential
Phaeophyta
01 natural sciences
Biochemistry
Algae
In vivo
Neoplasms
Drug Discovery
medicine
Animals
Humans
Biological Products
Clinical Trials as Topic
biology
Tumor hypoxia
010405 organic chemistry
Organic Chemistry
Cancer
biology.organism_classification
medicine.disease
Tubulin Modulators
0104 chemical sciences
Drug Resistance, Neoplasm
Cancer cell
Rhodophyta
Neoplastic Stem Cells
Tumor Hypoxia
Efflux
Signal transduction
Subjects
Details
- ISSN :
- 14604752
- Volume :
- 36
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Natural product reports
- Accession number :
- edsair.doi.dedup.....32fdaa0eded49e3b2ea735c62722410c