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Optimization and characterization of ultrasound assisted preparation of curcumin-loaded solid lipid nanoparticles: Application of central composite design, thermal analysis and X-ray diffraction techniques
- Source :
- Ultrasonics Sonochemistry. 38:271-280
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- This study is devoted to preparation of novel solid lipid nanoparticles (SLNs) for the encapsulation of curcumin which is produced by micro-emulsion and ultrasonication using stearic acid and tripalmitin as solid lipids, tween80 and span80 as surfactants. The relation between particle size and entrapment efficiency of the produced SLNs was operated by central composite design (CCD) under response likes surface method (RSM). The variables including the ratio of lipids (X1), the ratio of surfactants (X2), drug/lipid ratio (X3), time of sonication (X4) and time of homogenization (X5). Particle size and entrapment efficiency of the loaded curcumin was justified according to the minimum particle size and maximum entrapment efficiency. The curcumin loaded SLNs presented fairly spherical shape with the mean diameter and entrapment efficiency of 112.0±2.6nm and 98.7±0.3%, respectively. The optimized SLNs were characterized by X-ray diffraction analysis (XRD), differential scanning calorimetry (DSC), photon correlation spectroscopy (PCS) and field emission scanning electron microscopy (FESEM). The drug release profile of the optimal formulated material was examined in aqueous media and almost 30% of the curcumin loaded in SLNs was gradually released during 48h, which reveals efficient prolonged release of the drug.
- Subjects :
- Curcumin
Materials science
Acoustics and Ultrasonics
Central composite design
Sonication
Analytical chemistry
02 engineering and technology
010402 general chemistry
01 natural sciences
Inorganic Chemistry
chemistry.chemical_compound
Differential scanning calorimetry
X-Ray Diffraction
Dynamic light scattering
Solid lipid nanoparticle
Chemical Engineering (miscellaneous)
Environmental Chemistry
Radiology, Nuclear Medicine and imaging
Particle Size
Drug Carriers
Organic Chemistry
Temperature
021001 nanoscience & nanotechnology
Lipids
0104 chemical sciences
body regions
Drug Liberation
Ultrasonic Waves
Chemical engineering
chemistry
Tripalmitin
Nanoparticles
Particle size
Stearic acid
0210 nano-technology
Subjects
Details
- ISSN :
- 13504177
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Ultrasonics Sonochemistry
- Accession number :
- edsair.doi.dedup.....32eea230d716e6720c7c06dbf995db38