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Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina
- Publication Year :
- 2012
- Publisher :
- Society of Photo-Optical Instrumentation Engineers, 2012.
-
Abstract
- This study is to test anatomic correlates, including connecting cilium (CC) and inner segment (IS) ellipsoid, to the hyper-reflective band visualized by optical coherence tomography (OCT) and commonly attributed to the photoreceptor inner/outer segment (IS/OS) junction. A line-scan OCT (LS-OCT) was constructed to achieve sub-cellular resolution (lateral: ≈ 2 μm; axial: ≈ 4 μm) of excised living frog retinas. An electro-optic phase modulator was employed for rapid and vibration-free phase modulation. Comparison of normalized distance measurements between LS-OCT images and histological images revealed that the dominant source of the signal reported as the IS/OS OCT band actually originates from the IS.
- Subjects :
- Optics and Photonics
Retinal Photoreceptor Cell Outer Segment
genetic structures
Light
Ranidae
Biomedical Engineering
Signal
Light scattering
Retina
Biomaterials
Optics
Optical coherence tomography
medicine
Animals
Physics
medicine.diagnostic_test
business.industry
Resolution (electron density)
Reproducibility of Results
Signal Processing, Computer-Assisted
Equipment Design
JBO Letters
Atomic and Molecular Physics, and Optics
eye diseases
Electronic, Optical and Magnetic Materials
Electrophysiology
medicine.anatomical_structure
Inner segment
sense organs
business
Phase modulation
Algorithms
Tomography, Optical Coherence
Photoreceptor Cells, Vertebrate
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....32d6c4ef28cc5b2d64bcae88c85716b8