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Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials
- Source :
- Advanced Healthcare Materials. 7:1800490
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Regenerative medicine technologies rely heavily on the use of well-designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.
- Subjects :
- 0301 basic medicine
Tissue Engineering
Computer science
Inflammatory response
Biomedical Engineering
Pharmaceutical Science
Biomaterial
Biocompatible Materials
Nanotechnology
Regenerative Medicine
Regenerative medicine
Biomaterials
03 medical and health sciences
030104 developmental biology
Immune system
Tissue engineering
Biomimetics
Subjects
Details
- ISSN :
- 21922659 and 21922640
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Advanced Healthcare Materials
- Accession number :
- edsair.doi.dedup.....32ceb7a98c822ae4d9815ef3f7cf89e9