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Quercetin fail to protect against the neurotoxic effects of chronic homocysteine administration on motor behavior and oxidative stress in the adult rat’s cerebellum
- Source :
- Toxicol Res (Camb)
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Homocysteine (Hcy) is an excitatory amino acid that contains thiol group and derives from the methionine metabolism. It increases vulnerability of the neuronal cells to excitotoxic and oxidative damage. This study aimed to investigate the hyperhomocysteinemia (hHcy) effects on rat cerebellum and the possible protective role of quercetin administration in Hcy-treated rats, using behavioral and biochemical analyzes. To this end, the adult male rats were divided randomly into the control group that received vehicle, Hcy group received Hcy (400 μg/kg), Hcy + Que group received Hcy + quercetin (50 mg/kg), quercetin group received quercetin for 14 days. On Day 14 after the final treatment, lipid peroxidation level, the superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were evaluated in the cerebellum. After completion of treatment, the rat’s performance on rotarod and locomotor activity was evaluated. The results showed that Hcy treatment elicited cerebellar lipid peroxidation, impaired locomotor activity and increased latency to fall on the rotarod. Quercetin failed to attenuate significantly motoric impairment, increased significantly the cerebellar lipid peroxidation and GPx activity in the Hcy + Que group. Our results suggest that Hcy induced cerebellar toxicity and quercetin had no significant protective effects against Hcy toxicity in the cerebellum of adult rats.
- Subjects :
- Paper
0301 basic medicine
medicine.medical_specialty
Cerebellum
Hyperhomocysteinemia
Homocysteine
Health, Toxicology and Mutagenesis
Toxicology
medicine.disease_cause
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
heterocyclic compounds
chemistry.chemical_classification
030102 biochemistry & molecular biology
business.industry
Glutathione peroxidase
medicine.disease
Endocrinology
medicine.anatomical_structure
chemistry
Toxicity
business
Quercetin
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 20454538
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Toxicology Research
- Accession number :
- edsair.doi.dedup.....32bc3153b6bdca98ddc8ecfdaf5bbd9d