Back to Search
Start Over
Genomic estimation of additive and dominance effects and impact of accounting for dominance on accuracy of genomic evaluation in sheep populations
- Source :
- Journal of Animal Breeding and Genetics. 134:453-462
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- The objectives of this study were to estimate the additive and dominance variance component of several weight and ultrasound scanned body composition traits in purebred and combined cross-bred sheep populations based on single nucleotide polymorphism (SNP) marker genotypes and then to investigate the effect of fitting additive and dominance effects on accuracy of genomic evaluation. Additive and dominance variance components were estimated in a mixed model equation based on "average information restricted maximum likelihood" using additive and dominance (co)variances between animals calculated from 48,599 SNP marker genotypes. Genomic prediction was based on genomic best linear unbiased prediction (GBLUP), and the accuracy of prediction was assessed based on a random 10-fold cross-validation. Across different weight and scanned body composition traits, dominance variance ranged from 0.0% to 7.3% of the phenotypic variance in the purebred population and from 7.1% to 19.2% in the combined cross-bred population. In the combined cross-bred population, the range of dominance variance decreased to 3.1% and 9.9% after accounting for heterosis effects. Accounting for dominance effects significantly improved the likelihood of the fitting model in the combined cross-bred population. This study showed a substantial dominance genetic variance for weight and ultrasound scanned body composition traits particularly in cross-bred population; however, improvement in the accuracy of genomic breeding values was small and statistically not significant. Dominance variance estimates in combined cross-bred population could be overestimated if heterosis is not fitted in the model.
- Subjects :
- 0301 basic medicine
Mixed model
Heterosis
Restricted maximum likelihood
Population
Accounting
Breeding
Best linear unbiased prediction
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
Quantitative Trait, Heritable
Food Animals
Genetic variation
Animals
education
Genes, Dominant
Dominance (genetics)
education.field_of_study
Genome
Sheep
Models, Genetic
business.industry
Body Weight
0402 animal and dairy science
04 agricultural and veterinary sciences
General Medicine
040201 dairy & animal science
Phenotype
030104 developmental biology
Body Composition
Animal Science and Zoology
Metagenomics
business
Purebred
Subjects
Details
- ISSN :
- 09312668
- Volume :
- 134
- Database :
- OpenAIRE
- Journal :
- Journal of Animal Breeding and Genetics
- Accession number :
- edsair.doi.dedup.....329f463c69f13997fdd23d740f823b1d