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Nanoparticle Conjugation of Ginsenoside Rg3 Inhibits Hepatocellular Carcinoma Development and Metastasis
- Source :
- Small (Weinheim an der Bergstrasse, Germany). 16(2)
- Publication Year :
- 2019
-
Abstract
- Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. The prognosis of HCC remains very poor; thus, an effective treatment remains urgent. Herein, a type of nanomedicine is developed by conjugating Fe@Fe3 O4 nanoparticles with ginsenoside Rg3 (NpRg3), which achieves an excellent coupling effect. In the dimethylnitrosamine-induced HCC model, NpRg3 application significantly prolongs the survival of HCC mice. Further research indicates that NpRg3 application significantly inhibits HCC development and eliminates HCC metastasis to the lung. Notably, NpRg3 application delays HCC-induced ileocecal morphology and gut microbial alterations more than 12 weeks during HCC progression. NpRg3 administration elevates the abundance of Bacteroidetes and Verrucomicrobia, but decreases Firmicutes. Twenty-nine predicted microbial gene functions are enriched, while seven gene functions are reduced after NpRg3 administration. Moreover, the metabolomics profile presents a significant progression during HCC development, but NpRg3 administration corrects tumor-dominant metabolomics. NpRg3 administration decreases 3-indolepropionic acid and urea, but elevates free fatty acids. Importantly, NpRg3 application remodels the unbalanced correlation networks between gut microbiota and metabolism during HCC therapy. In conclusion, nanoparticle conjugation of ginsenoside Rg3 inhibits HCC development and metastasis via the remodeling of unbalanced gut microbiota and metabolism in vivo, providing an antitumor therapy strategy.
- Subjects :
- Carcinoma, Hepatocellular
Ginsenosides
02 engineering and technology
Gut flora
010402 general chemistry
01 natural sciences
Metastasis
Biomaterials
chemistry.chemical_compound
Mice
Metabolomics
In vivo
Cell Line, Tumor
medicine
Animals
Humans
General Materials Science
Neoplasm Metastasis
neoplasms
Lung
biology
business.industry
Liver Neoplasms
General Chemistry
Metabolism
021001 nanoscience & nanotechnology
medicine.disease
biology.organism_classification
digestive system diseases
0104 chemical sciences
medicine.anatomical_structure
chemistry
Ginsenoside
Hepatocellular carcinoma
Cancer research
Nanoparticles
0210 nano-technology
business
Biotechnology
Subjects
Details
- ISSN :
- 16136829
- Volume :
- 16
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Accession number :
- edsair.doi.dedup.....3287c1478ba01a3053bb62cf2abb6037