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Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People
- Source :
- Nutrients; Volume 9; Issue 11; Pages: 1199, Nutrients, Vol 9, Iss 11, p 1199 (2017), Nutrients
- Publication Year :
- 2017
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2017.
-
Abstract
- Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1). Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study. The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months. A microarray analysis and subsequent quantitative real-time polymerase chain reaction (qRT-PCR) analysis of peripheral blood mononuclear cells (PBMCs) showed decreased expression of CCL24, an inflammatory chemokine (p < 0.05). Verbal memory, assessed using the Wechsler memory scale–logical memory, was preserved in the ACS group. An age-restricted sub-analysis showed significant verbal memory preservation by ACS in participants who were in their 60s (active, n = 12; placebo, n = 9; p = 0.048) and 70s (active, n = 7; placebo, n = 11; p = 0.017). The suppression of CCL24 expression was greatest in people who were in their 70s (p < 0.01). There was a significant correlation between the preservation of verbal memory and suppression of CCL24 expression in the group that was in the 70s (Poisson correlation, r = 0.46, p < 0.05). These results suggest that ACS may preserve verbal episodic memory, probably owing to CCL24 suppression in the blood, especially in elderly participants.
- Subjects :
- Male
0301 basic medicine
Aging
Chemokine
Time Factors
Carnosine
chemistry.chemical_compound
Cognition
0302 clinical medicine
Medicine
Anserine
Episodic memory
Nutrition and Dietetics
biology
Age Factors
Middle Aged
Drug Combinations
Treatment Outcome
Female
anserine and carnosine
Inflammation Mediators
Alzheimer’s disease
lcsh:Nutrition. Foods and food supply
RCT
Adult
medicine.medical_specialty
Memory, Episodic
Down-Regulation
inflammatory chemokine
lcsh:TX341-641
verbal memory
Placebo
Peripheral blood mononuclear cell
Article
03 medical and health sciences
Double-Blind Method
Internal medicine
Humans
Tokyo
cognitive function
elderly people
CCL24
Aged
Memory Disorders
business.industry
Chemokine CCL24
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
Immunology
Leukocytes, Mononuclear
biology.protein
Verbal memory
business
Biomarkers
030217 neurology & neurosurgery
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients; Volume 9; Issue 11; Pages: 1199
- Accession number :
- edsair.doi.dedup.....32759e220bf5ebc103dcc1cfd10b5153
- Full Text :
- https://doi.org/10.3390/nu9111199