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Importins and exportins in cellular differentiation
- Source :
- Journal of Cellular and Molecular Medicine
- Publication Year :
- 2008
-
Abstract
- The importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport. Alterations of the levels of importins and exportins may play crucial roles in development, differentiation and transformation. Employing human leukaemia HL-60 cells, we and others have revealed the differentiation-associated changes in the protein and gene expression of these factors. The recent finding that a switch to the importin-alpha subtype triggers neural differentiation of embryonic stem cells underscores the importance of nucleocytoplasmic transport factors in cellular events. This review focuses on current research into the roles of importins and exportins in cell differentiation.
- Subjects :
- importin·
animal structures
Cellular differentiation
exportin
Active Transport, Cell Nucleus
Reviews
HL-60 Cells
Importin
Biology
Karyopherins
environment and public health
Models, Biological
Gene expression
medicine
Humans
Regulation of gene expression
Cell Nucleus
nucleocytoplasmic transport
Cell Differentiation
Cell Biology
differentiation
Embryonic stem cell
Cell biology
Gene Expression Regulation, Neoplastic
Cell nucleus
medicine.anatomical_structure
Nucleocytoplasmic Transport
embryonic structures
gene expression
Molecular Medicine
Subjects
Details
- ISSN :
- 15821838
- Volume :
- 12
- Issue :
- 5B
- Database :
- OpenAIRE
- Journal :
- Journal of cellular and molecular medicine
- Accession number :
- edsair.doi.dedup.....326d530aba05a8d0b063bde92e245792