Prevalence of Maturity-Onset Diabetes of the Young Mutations in Brazilian Families With Autosomal- Dominant Early-Onset Type 2 Diabetes

The relative frequencies of the subtypes of maturity-onset diabetes of the young (MODY) were shown to vary greatly in studies from different populations (1–4). The Brazilian population has mixed ethnic background (African, Asian, European-Caucasian of several different countries of origin, and Indigenous), and little is known about the genetic determinants of diabetes in Brazilians. In this report, we describe the frequencies of the major MODY subtypes in a panel of 12 Brazilian families with autosomal-dominant early-onset type 2 diabetes (Fig. 1). A total of 32 family members were studied. The age at diagnosis of diabetes was