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Molecular epidemiological analysis of Japanese encephalitis virus in China
- Source :
- Journal of General Virology. 88:885-894
- Publication Year :
- 2007
- Publisher :
- Microbiology Society, 2007.
-
Abstract
- Sixty-two new Japanese encephalitis virus (JEV) isolates were obtained from mosquitoes, biting midges, human cerebrospinal fluid and human blood samples in China during 2002–2005. The E and prM genes were sequenced and phylogenetic analyses were performed with 38 JEV other isolates from China and 36 JEV strains from other countries. Phylogenetic trees based on the E and prM gene sequences were similar. The results indicate that: (i) recent JEV isolates from China are divided into two genotypes, genotype 1 and genotype 3; (ii) recent JEV isolates from China are grouped into the same clusters within genotypes 1 and 3; and (iii) genotype 1 JEV strains have been isolated in China since 1979, whilst genotype 3 JEV strains were isolated before the 1970s. The results suggest that genotype 1 JEV was introduced to China around 1979 and that JEV strains belonging to genotypes 1 and 3 circulate in China.
- Subjects :
- China
Genes, Viral
viruses
Molecular Sequence Data
Sequence Homology
Ceratopogonidae
Virus
Viral Proteins
Flaviviridae
Viral Envelope Proteins
Virology
Genotype
medicine
Animals
Humans
Encephalitis, Japanese
Phylogeny
Cerebrospinal Fluid
Encephalitis Virus, Japanese
Molecular Epidemiology
Membrane Glycoproteins
Phylogenetic tree
biology
Molecular epidemiology
Sequence Analysis, DNA
Japanese encephalitis
medicine.disease
biology.organism_classification
Flavivirus
Blood
Culicidae
RNA, Viral
Encephalitis
Subjects
Details
- ISSN :
- 14652099 and 00221317
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Journal of General Virology
- Accession number :
- edsair.doi.dedup.....32373bf4b83f2ecdf8910ccaa93183dd