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Impact of Immune Response on Outcomes in Hepatocellular Carcinoma: Association With Vascular Formation
- Source :
- Hepatology (Baltimore, Md.)References. 72(6)
- Publication Year :
- 2019
-
Abstract
- BACKGROUND AND AIMS We investigated the prognostic value of programmed death ligand 1 (PD-L1) expression, tumor-infiltrating CD8-positive T-cell status, and their combination in hepatocellular carcinoma (HCC). Their association with PD-L1 expression and vascular formation was further explored. APPROACH AND RESULTS Using a database of 387 patients who underwent hepatic resection for HCC, immunohistochemical staining of PD-L1, CD8, and CD34 was performed. Additionally, we undertook an enzyme-linked immunosorbent assay for soluble PD-L1. Compared with patients with HCC and PD-L1-negative expression (n = 311), patients with HCC and PD-L1-positive expression (n = 76) showed significantly worse overall survival (OS; multivariate hazard ratio, 2.502; 95% confidence interval [CI], 1.716-3.649; P
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
Adolescent
CD34
Kaplan-Meier Estimate
CD8-Positive T-Lymphocytes
Gastroenterology
Risk Assessment
B7-H1 Antigen
Disease-Free Survival
03 medical and health sciences
Young Adult
0302 clinical medicine
Immune system
Lymphocytes, Tumor-Infiltrating
Internal medicine
Tumor Microenvironment
Medicine
Hepatectomy
Humans
Aged
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
Hepatology
Neovascularization, Pathologic
business.industry
Hazard ratio
Liver Neoplasms
Middle Aged
medicine.disease
Prognosis
Magnetic Resonance Imaging
Confidence interval
030104 developmental biology
Liver
Hepatocellular carcinoma
Cancer cell
Immunohistochemistry
030211 gastroenterology & hepatology
Female
Neoplasm Recurrence, Local
business
Tomography, X-Ray Computed
CD8
Follow-Up Studies
Subjects
Details
- ISSN :
- 15273350
- Volume :
- 72
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Hepatology (Baltimore, Md.)References
- Accession number :
- edsair.doi.dedup.....32362e5c0d88bef5771c6d7948fe1e3f