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Lack of Cytomegalovirus Transmission after Pancreatic Islet Transplantation
- Source :
- Cell Transplantation, Vol 13 (2004)
- Publication Year :
- 2004
- Publisher :
- SAGE Publications, 2004.
-
Abstract
- In spite of antiviral prophylaxis, the transmission rate of cytomegalovirus (CMV) after solid organ transplantation remains high. In contrast, CMV transmission has never been reported following pancreatic islet transplantation (PIT). Eleven (seven CMV seronegative, four CMV seropositive) recipients underwent a total of 26 PITs. Following PIT recipients were monitored clinically and tested monthly for CMV antigenemia. Valganciclovir was given to all patients for 100 days after each PIT. Follow-up ranged from 6 to 24 months (median 14.5 months). Pancreatic islet grafts were procured from 18 CMV seropositive and 8 seronegative donors (69% and 31% of donors, respectively). In total there were 6 R+D+, 3 R+D-, 12 R-D+, and 5 R-D-PITs. No patient developed CMV antigenemia or symptoms consistent with CMV infection at any time following PIT. Routine posttransplant testing of PIT recipients demonstrated that neither CMV transmission nor CMV infection occurred after PIT.
- Subjects :
- Adult
Male
0301 basic medicine
Ganciclovir
medicine.medical_specialty
Iatrogenic Disease
Islets of Langerhans Transplantation
Biomedical Engineering
Congenital cytomegalovirus infection
Cytomegalovirus
lcsh:Medicine
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
Diabetes Mellitus
Humans
Valganciclovir
Medicine
Transplantation
geography
geography.geographical_feature_category
business.industry
Transmission (medicine)
lcsh:R
virus diseases
Cell Biology
Length of Stay
Middle Aged
Islet
medicine.disease
Virology
Treatment Outcome
030104 developmental biology
Cytomegalovirus Infections
Female
Pancreatic islet transplantation
Solid organ transplantation
business
030217 neurology & neurosurgery
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 15553892 and 09636897
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cell Transplantation
- Accession number :
- edsair.doi.dedup.....322448ddb16e584de89c9741943b99f6