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Ubiquitin-related molecular classification and risk stratification of hepatocellular carcinoma
- Source :
- Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 207-219 (2021), Molecular Therapy Oncolytics
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- The roles of ubiquitin-related genes in hepatocellular carcinoma (HCC) have not been thoroughly investigated. This study aimed to systematically examine ubiquitin-related genes and identify subtypes and stratify prognosis of HCC by using ubiquitin-related signatures. Survival, biological processes, tumor microenvironment (TME), and genomic alterations of the HCC subtypes were investigated. Patients with HCC were classified into two subtypes (clusters 1 and 2) with distinct survival outcomes, pathways, and genomic alterations. Cluster 2 had better prognosis than did cluster 1. Hepatitis B, hepatitis C, Janus tyrosine kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, and natural killer cell-mediated cytotoxicity were enriched in cluster 1. Moreover, cluster 2 had a higher immune score and immune cell infiltrations, whereas cluster 1 had a lower immune score and immune infiltrations. Additionally, mutations, amplifications, and deletions among the phosphatidylinositol 3-kinase (PI3K)-AKT, p53, and receptor tyrosine kinase (RTK)-RAS pathways more frequently occurred in cluster 1, while those among the Hippo, MYC, and Notch signaling pathways were found in cluster 2. Finally, a prognostic signature, consisting of eight ubiquitin-related genes, was established and validated. In brief, our study established a new classification and developed a prognostic signature for HCC.<br />Graphical abstract<br />This study aimed to examine ubiquitin-related genes and identify subtypes and stratify prognosis of HCC by using ubiquitin-related signatures. Patients with HCC were classified into two subtypes with distinct survival outcomes, pathways, and genomic alterations. Additionally, a prognostic signature, consisting of eight ubiquitin-related genes, was established and validated for HCC.
- Subjects :
- 0301 basic medicine
Cancer Research
Notch signaling pathway
risk stratification
ubiquitination
Receptor tyrosine kinase
03 medical and health sciences
0302 clinical medicine
Immune system
medicine
Pharmacology (medical)
PI3K/AKT/mTOR pathway
RC254-282
Tumor microenvironment
biology
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
hepatocellular carcinoma
Hepatitis B
medicine.disease
molecular subtype
ubiquitin-related genes
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Cancer research
biology.protein
Molecular Medicine
Original Article
Tyrosine kinase
Subjects
Details
- Language :
- English
- ISSN :
- 23727705
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecular Therapy: Oncolytics
- Accession number :
- edsair.doi.dedup.....32117ee7c82857c6de2a6ff3cbbf1933