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Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex
- Source :
- Journal of Cerebral Blood Flow & Metabolism. 38:347-359
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called “blobs” and “interblobs”) with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
- Subjects :
- Magnetic Resonance Spectroscopy
media_common.quotation_subject
Color
Glutamic Acid
Biology
030218 nuclear medicine & medical imaging
law.invention
Electron Transport Complex IV
03 medical and health sciences
0302 clinical medicine
Neurochemical
law
medicine
Humans
Contrast (vision)
Lactic Acid
Chromatic scale
Visual Cortex
media_common
Brain Chemistry
Neurons
Aspartic Acid
Lactate concentration
Glutamate receptor
Original Articles
Magnetic Resonance Imaging
Neuronal activation
Healthy Volunteers
Glucose
Visual cortex
medicine.anatomical_structure
Neurology
Achromatic lens
Evoked Potentials, Visual
Neurology (clinical)
Energy Metabolism
Cardiology and Cardiovascular Medicine
Oxidation-Reduction
Neuroscience
Photic Stimulation
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15597016 and 0271678X
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Cerebral Blood Flow & Metabolism
- Accession number :
- edsair.doi.dedup.....320906ac2b08b79b540e9b3222f0cb33