Back to Search
Start Over
Electronic Cortisol Detection Using an Antibody-Embedded Polymer Coupled to a Field-Effect Transistor
- Source :
- ACS Applied Materials & Interfaces. 10:16233-16237
- Publication Year :
- 2018
- Publisher :
- American Chemical Society (ACS), 2018.
-
Abstract
- A field-effect transistor-based cortisol sensor was demonstrated in physiological conditions. An antibody-embedded polymer on the remote gate was proposed to overcome the Debye length issue (λ(D)). The sensing membrane was made by linking poly(styrene-co-methacrylic acid) (PSMA) with anticortisol before coating the modified polymer on the remote gate. The embedded receptor in the polymer showed sensitivity from 10 fg/mL to 10 ng/mL for cortisol and a limit of detection (LOD) of 1 pg/mL in 1× PBS where λ(D) is 0.2 nm. A LOD of 1 ng/mL was shown in lightly buffered artificial sweat. Finally, a sandwich ELISA confirmed the antibody binding activity of antibody-embedded PSMA.
- Subjects :
- Materials science
Hydrocortisone
Transistors, Electronic
Polymers
Biosensing Techniques
02 engineering and technology
010402 general chemistry
01 natural sciences
Article
law.invention
symbols.namesake
law
General Materials Science
Debye length
chemistry.chemical_classification
Detection limit
Chromatography
biology
Transistor
Equipment Design
Polymer
021001 nanoscience & nanotechnology
Antigen binding
0104 chemical sciences
Membrane
chemistry
symbols
biology.protein
Field-effect transistor
Antibody
0210 nano-technology
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....31f6fa14aa5bc1485504e7c7acac3d23