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Intra-household agreement of urinary elemental concentrations in Tanzania and Kenya: potential surrogates in case-control studies
- Source :
- Journal of exposure science & environmental epidemiology
- Publication Year :
- 2018
-
Abstract
- Element deficiencies and excesses play important roles in non-communicable disease aetiology. When investigating their roles in epidemiologic studies without prospective designs, reverse-causality limits the utility of transient biomarkers in cases. This study aimed to investigate whether surrogate participants may provide viable proxies by assessing concentration correlations within households. We obtained spot urine samples from 245 Tanzanian and Kenyan adults (including 101 household pairs) to investigate intra-household correlations of urinary elements (As, Ba, Ca, Cd, Co, Cs, Cu, Fe, Li, Mn, Mo, Ni, Pb, Rb, S, Se, Sr, Tl, V and Zn) and concentrations (also available for: Bi, Ce, Sb, Sn and U) relative to external population-levels and health-based values. Moderate-strong correlations were observed for As (r = 0.65), Cs (r = 0.67), Li (r = 0.56), Mo (r = 0.57), Se (r = 0.68) and Tl (r = 0.67). Remaining correlations were
- Subjects :
- Adult
Male
Adolescent
Epidemiology
trace elements
Urine
030501 epidemiology
Toxicology
Tanzania
Article
03 medical and health sciences
Young Adult
Animal science
Humans
Prospective Studies
Aged
Family Characteristics
Chemistry
Public Health, Environmental and Occupational Health
Case-control study
Middle Aged
Micronutrient
Pollution
Kenya
urine
3. Good health
Spot urine
Case-Control Studies
micronutrients
Female
0305 other medical science
Biomarkers
cancer epidemiology
Subjects
Details
- ISSN :
- 1559064X
- Volume :
- 29
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of exposure scienceenvironmental epidemiology
- Accession number :
- edsair.doi.dedup.....31f265ecc401c747c1401b25346740f9