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Elevated plasma soluble interleukin 2 receptor level correlates with defective natural killer and CD8+ T-cells in myelodysplastic syndromes
- Source :
- Leukemia Research. 18:777-782
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- The plasma soluble interleukin 2 receptor (sIL-2R) level and its relationships with haematologic and immunologic data were examined in 40 patients with myelodysplastic syndromes (MDS). The plasma sIL-2R level was significantly higher in the high-risk MDS group (refractory anaemia with excess blasts (RAEB), RAEB in transformation and chronic myelomonocytic leukaemia) than in the low-risk MDS group (refractory anaemia (RA) and RA with ringed sideroblasts) or in normal subjects, although there was considerable variation in the plasma sIL-2R level within each MDS group. The plasma sIL-2R level correlated positively with the bone marrow cellularity and bone marrow blast mass, but not with the absolute number of CD25+ lymphocytes. This may support the idea that plasma sIL-2R is derived from malignant MDS cells in the bone marrow. The plasma sIL-2R level correlated negatively with the absolute numbers of the CD8+, CD3-CD16+, and CD3-CD56+ cell populations in freshly isolated lymphocytes, the percentage of CD3-CD56+ cells in lymphokine (interleukin 2)-activated killer (LAK) cells, and the cytotoxicity of LAK cells. We conclude that MDS patients having a high plasma sIL-2R level often have a defect in natural killer and CD8+ T-cells.
- Subjects :
- Adult
Interleukin 2
Cancer Research
medicine.medical_specialty
CD8-Positive T-Lymphocytes
Biology
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Cytotoxic T cell
IL-2 receptor
Killer Cells, Lymphokine-Activated
Aged
Anemia, Refractory, with Excess of Blasts
Lymphokine-activated killer cell
Myelodysplastic syndromes
Anemia, Refractory
Lymphokine
Leukemia, Myelomonocytic, Chronic
Receptors, Interleukin-2
Hematology
Middle Aged
medicine.disease
Endocrinology
medicine.anatomical_structure
Oncology
Immunology
Bone marrow
CD8
medicine.drug
Subjects
Details
- ISSN :
- 01452126
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Leukemia Research
- Accession number :
- edsair.doi.dedup.....31efc74bf0451fa687a30a338c6650fb