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Evaluation of the dose-effect association between the number of doses and duration since the last dose of COVID-19 vaccine, and its efficacy in preventing the disease and reducing disease severity: A single centre, cross-sectional analytical study from India
- Source :
- Diabetes & Metabolic Syndrome
- Publication Year :
- 2021
- Publisher :
- Diabetes India. Published by Elsevier Ltd., 2021.
-
Abstract
- Aims To evaluate the dose-effect association between COVID-19 vaccination and probability of turning RT-PCR positive and to assess the correlation between disease severity and vaccination status. Methods A single centre cross-sectional study was conducted amongst 583 individuals presenting to COVID-19 testing clinic and 55 hospitalized COVID-19 patients. Vaccination status was assessed by the number of doses and duration since the last dose. Disease severity was evaluated by the requirement of hospitalisation and ICU admission/death. The association between the vaccination status and development of disease and its severity were statistically analyzed. Results The mean age of the population was 36.6 years and 82.6% had no comorbidities. The odds of turning RT-PCR positive was 0.17(95% CI: 0.11–0.27) among the clinical suspects who had taken both doses of the vaccine at least 14 days before (fully vaccinated). The odds of hospitalisation was 0.12(95% CI: 0.03–0.45) and ICU admission/death was 0.07(95% CI: 0.01–0.36) among fully vaccinated individuals. The protective role of vaccination was observed to start 14 days after receiving the first dose. Conclusions COVID-19 vaccination provides dose-dependent protection against the development of the disease. It also lowers the risk of hospitalisation and ICU admission/death in RT-PCR positive patients in a dose-dependent manner.
- Subjects :
- Adult
Male
medicine.medical_specialty
COVID-19 Vaccines
Time Factors
Coronavirus disease 2019 (COVID-19)
Endocrinology, Diabetes and Metabolism
Population
RT-PCR
India
Disease
Severity of Illness Index
Article
Drug Administration Schedule
Odds
Young Adult
COVID-19 Testing
Disease severity
Internal medicine
Diabetes mellitus
Internal Medicine
Medicine
Humans
education
Vaccine Potency
Immunization Schedule
education.field_of_study
Dose-Response Relationship, Drug
business.industry
Vaccination
COVID-19
Protective efficacy
General Medicine
Middle Aged
medicine.disease
Covishield
Hospitalization
Single centre
Cross-Sectional Studies
Treatment Outcome
Covaxin
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 18780334 and 18714021
- Volume :
- 15
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolic Syndrome
- Accession number :
- edsair.doi.dedup.....31ecd760b12e021e8263ff00d171a141