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Transient Uptake and Storage of Serotonin in Developing Thalamic Neurons
- Source :
- Neuron. 17(5):823-835
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Serotonin (5-HT) has been shown to affect the development and patterning of the mouse barrelfield. We show that the dense transient 5-HT innervation of the somatosensory, visual, and auditory cortices originates in the thalamus rather than in the raphe: 5-HT is detected in thalamocortical fibers and most 5-HT cortical labeling disappears after thalamic lesions. Thalamic neurons do not synthesize 5-HT but take up exogenous 5-HT through 5-HT high affinity uptake sites located on thalamocortical axons and terminals. 3H–5-HT injected into the cortex is retrogradely transported to thalamic neurons. In situ hybridization shows a transient expression of the genes encoding the serotonin transporter and the vesicular monoamine transporter in thalamic sensory neurons. In these glutamatergic neurons, internalized 5-HT might thus be stored and used as a “borrowed transmitter” for extraneuronal signaling or could exert an intraneuronal control on thalamic maturation.
- Subjects :
- Serotonin
Time Factors
Neuroscience(all)
Thalamus
Gene Expression
Sensory system
Nerve Tissue Proteins
Tritium
Rats, Sprague-Dawley
Glutamatergic
Mice
Antibody Specificity
Vesicular Biogenic Amine Transport Proteins
medicine
Animals
Neurons, Afferent
RNA, Messenger
Serotonin transporter
In Situ Hybridization
Cerebral Cortex
Serotonin Plasma Membrane Transport Proteins
Neurotransmitter Agents
Membrane Glycoproteins
biology
Raphe
General Neuroscience
Neuropeptides
Age Factors
Membrane Transport Proteins
Biological Transport
Immunohistochemistry
Rats
Vesicular monoamine transporter
Mice, Inbred C57BL
medicine.anatomical_structure
Cerebral cortex
Vesicular Monoamine Transport Proteins
biology.protein
Synaptic Vesicles
Carrier Proteins
Neuroscience
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 17
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....31d2944bfceb42136c25ceb54a8b0b15
- Full Text :
- https://doi.org/10.1016/s0896-6273(00)80215-9