Back to Search
Start Over
Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma
- Source :
- Cancer Letters. 264:209-217
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- LAPTM4B was proven to overexpress in hepatocellular carcinoma and relate to differentiation. We immunohistochemically investigated the expression and potential clinicopathological and prognostic significance of LAPTM4B encoded protein, LAPTM4B-35, in extrahepatic cholangiocarcinoma (EHCC) for specimens from consecutive 81 patients. LAPTM4B-35 staining was positive in cancer tissues from 59 patients (72.8%), including 12 with score 1, 22 with score 2 and 25 with score 3. No positive staining was found in non-cancer epithelia. The staining score in cancer tissues was not only significantly associated with TNM staging, histological grade, perineural and lymph node invasion (P < 0.05), but also of comprehensive prognostic implications, including integrated estimation with CA19-9. These data established that LAPTM4B-35 positively expressed in a great portion of EHCC and might be a novel molecular maker of progression, invasiveness and poor prognosis.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Pathology
Poor prognosis
Kaplan-Meier Estimate
Biology
Disease-Free Survival
Cholangiocarcinoma
Extrahepatic Cholangiocarcinoma
LAPTM4B
Bile Ducts, Extrahepatic
Internal medicine
Biomarkers, Tumor
medicine
Humans
Neoplasm Invasiveness
Lymph node
Aged
Neoplasm Staging
Aged, 80 and over
Oncogene Proteins
Membrane Proteins
Cancer
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Staining
medicine.anatomical_structure
Bile Duct Neoplasms
Hepatocellular carcinoma
Disease Progression
Female
Positive staining
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 264
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....31c029f2ea3e8035a8f44c88e61b5f24