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Response inhibition in borderline personality disorder: Neural and behavioral correlates
- Source :
- Biological psychology. 143
- Publication Year :
- 2018
-
Abstract
- Although response inhibition is thought to be important in borderline personality disorder (BPD), little is known about its neurophysiological basis. This study aimed to provide insight into this issue by capitalizaing on the high temporal resolution of electroencephalography and information provided by source localization methods. To this end, twenty unmedicated patients with BPD and 20 healthy control subjects performed a modified go/no-go task designed to better isolate the brain activity specifically associated with response inhibition. Event-related potentials (ERP) were measured and further analyzed at the scalp and source levels. Patients with BPD made more commission errors (failed inhibitions) than control subjects. Scalp ERP data showed that both groups displayed greater frontocentral P3 amplitude for no-go (response inhbition) than for go trials (response execution). However, source reconstruction data revealed that patients with BPD activated posterior parietal regions (precuneus) to inhibit their responses, whereas controls activated prefrontal regions (presupplementary motor area, preSMA). This dissociation was supported by a significant Region (precuneus, preSMA) x Trial Type (no-go, go) x Group (BPD, control) interaction. These findings extend our understanding of the neurophysiological basis of abnormal response inhibition in BPD, suggesting that patients with BPD recruit different brain regions for inhibiting prepotent responses compared to controls. Future research in larger, medication-naive samples of patients with BPD is required to confirm and extend these findings.
- Subjects :
- Adult
Male
medicine.medical_specialty
Dissociation (neuropsychology)
Brain activity and meditation
Precuneus
Prefrontal Cortex
Audiology
Electroencephalography
behavioral disciplines and activities
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Borderline Personality Disorder
Parietal Lobe
mental disorders
Task Performance and Analysis
medicine
Humans
0501 psychology and cognitive sciences
Borderline personality disorder
Evoked Potentials
Response inhibition
medicine.diagnostic_test
business.industry
General Neuroscience
05 social sciences
Brain
Neurophysiology
medicine.disease
Inhibition, Psychological
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
Scalp
Case-Control Studies
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18736246
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- Biological psychology
- Accession number :
- edsair.doi.dedup.....31be424b45763eae7a1006f4cc53fb25