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Gentamicin, norfloxacin and lysozyme concentration in human tears: in vivo and in vitro study

Authors :
C. Garcher
A. Lallemand
C. Bonnin
A.M. Bron
ProdInra, Migration
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)
Source :
Acta Ophthalmologica Scandinavica-Supplement, Acta Ophthalmologica Scandinavica-Supplement-, 1992, 70 (6), pp.750-753
Publication Year :
2009
Publisher :
Wiley, 2009.

Abstract

Hen's egg lysozyme (HEL) activity was measured in vitro with gentamicin and norfloxacin by a turbidimetric technique. Gentamicin at the concentration of 10(-3) M inhibited HEL activity by 39%, while 10(-3) M norfloxacin did not affect HEL activity. However, an in vivo study in healthy persons did not show any significant statistical difference in tear lysozyme activity when 0.3% gentamicin or 0.3% norfloxacin were topically applied.

Details

ISSN :
1755375X and 13953931
Volume :
70
Database :
OpenAIRE
Journal :
Acta Ophthalmologica
Accession number :
edsair.doi.dedup.....31baa7462c922e6a969215521096b152