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Gentamicin, norfloxacin and lysozyme concentration in human tears: in vivo and in vitro study
- Source :
- Acta Ophthalmologica Scandinavica-Supplement, Acta Ophthalmologica Scandinavica-Supplement-, 1992, 70 (6), pp.750-753
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Hen's egg lysozyme (HEL) activity was measured in vitro with gentamicin and norfloxacin by a turbidimetric technique. Gentamicin at the concentration of 10(-3) M inhibited HEL activity by 39%, while 10(-3) M norfloxacin did not affect HEL activity. However, an in vivo study in healthy persons did not show any significant statistical difference in tear lysozyme activity when 0.3% gentamicin or 0.3% norfloxacin were topically applied.
- Subjects :
- Adult
Male
Adolescent
Egg lysozyme
chemical and pharmacologic phenomena
In Vitro Techniques
gentamicin
Pharmacology
Microbiology
Cornea
chemistry.chemical_compound
In vivo
medicine
Humans
In vitro study
heterocyclic compounds
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
lysozyme
Norfloxacin
ocular surface
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Chemistry
hemic and immune systems
General Medicine
biochemical phenomena, metabolism, and nutrition
infection
In vitro
Ophthalmology
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Tears
Muramidase
Gentamicin
Gentamicins
Ophthalmic Solutions
Lysozyme
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
medicine.drug
Subjects
Details
- ISSN :
- 1755375X and 13953931
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Acta Ophthalmologica
- Accession number :
- edsair.doi.dedup.....31baa7462c922e6a969215521096b152