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Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability
- Source :
- Pharmaceutics; Volume 15; Issue 3; Pages: 907
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- (1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)—a new anticoagulation drug—has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10−6 cm/s across Caco-2 colonic cells), thus resulting in a low oral bioavailability of
Details
- ISSN :
- 19994923
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....31b4552c6ea16db6cb571ccde12c3953