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Immunopathogenesis and therapy of cutaneous T cell lymphoma
- Source :
- Journal of Clinical Investigation. 115:798-812
- Publication Year :
- 2005
- Publisher :
- American Society for Clinical Investigation, 2005.
-
Abstract
- Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally derived, skin-invasive T cells. Mycosis fungoides (MF) and Sezary syndrome (SS) are the most common types of CTCLs and are characterized by malignant CD4(+)/CLA(+)/CCR4(+) T cells that also lack the usual T cell surface markers CD7 and/or CD26. As MF/SS advances, the clonal dominance of the malignant cells results in the expression of predominantly Th2 cytokines, progressive immune dysregulation in patients, and further tumor cell growth. This review summarizes recent insights into the pathogenesis and immunobiology of MF/SS and how these have shaped current therapeutic approaches, in particular the growing emphasis on enhancement of host antitumor immune responses as the key to successful therapy.
- Subjects :
- Skin Neoplasms
medicine.medical_treatment
T cell
T-Lymphocytes
Lymphoproliferative disorders
medicine.disease_cause
Immune system
Antigens, CD
T-Lymphocyte Subsets
Medicine
Humans
Neoplasm Staging
Skin
Mycosis fungoides
business.industry
Cutaneous T-cell lymphoma
Immunotherapy
General Medicine
Immune dysregulation
medicine.disease
Lymphoma
Lymphoma, T-Cell, Cutaneous
Survival Rate
medicine.anatomical_structure
Immunology
Science in Medicine
business
Corrigendum
Subjects
Details
- ISSN :
- 00219738
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....31aac0d0bbcf7f482cd09d01acad9ac2