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Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells
- Source :
- Journal of natural medicines. 74(4)
- Publication Year :
- 2020
-
Abstract
- From the methanolic extract of the aerial parts of Petasites japonicus, six new eremophilane-type sesquiterpenoids, petasitesterpenes I-VI were isolated together with eight known compounds including S-japonin and eremophilenolide. The chemical structures of the isolated new compounds were elucidated based on chemical/physicochemical evidence. For petasitesterpenes I and II, the absolute configurations were established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, petasitesterpenes I, II, VI, and S-japonin showed cytotoxic activity against both human astrocytoma U-251MG cancer cells (non-CSCs) and their cancer stem cells (CSCs) isolated by sphere formation. In addition, cytotoxic activities of these compounds against breast cancer MDA-MB-231 were evaluated, supporting that petasitesterpene II has more effective than other isolated compounds.
- Subjects :
- Circular dichroism
Plants, Medicinal
Molecular Structure
010405 organic chemistry
Chemistry
Pharmacology toxicology
Petasites japonicus
Eremophilenolide
Petasites
Sphere formation
01 natural sciences
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Biochemistry
Cancer stem cell
Cancer cell
Neoplastic Stem Cells
Molecular Medicine
Cytotoxic T cell
Humans
Sesquiterpenes
Subjects
Details
- ISSN :
- 18610293
- Volume :
- 74
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of natural medicines
- Accession number :
- edsair.doi.dedup.....31aa79c6a66a463e7411967de21e7030