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Identification of death risk factors of primary melanoma based on the competing risk model
- Source :
- Bulletin du cancer. 108(10)
- Publication Year :
- 2020
-
Abstract
- Summary Objective To preliminarily explore death risk factors in primary melanoma patients. Method Competing risk model analysis was used using a large sample public cohort and Cox proportional hazard model was compared. Result In the competing risk model analysis, age, gender, ethnicity, stage, site, TMN stage and metastases were the independent risk factors of single primary melanoma (SPM) death. T stage had a particularly important impact on SPM death. T2 stage had a 3.212 times greater risk of interest event than T1 stage [hazard ratio (HR) = 3.212, 95%CI: 2.994–3.446], T3 stage was 5.747 times greater than that T1 stage (HR = 5.747, 95%CI: 5.337–6.187) and T4 stage had a 7.086 times than T1 stage (HR = 7.086, 95%CI: 6.514–7.708). Gender, ethnicity, stage, site, T stage and brain and liver metastases were the independent risk factors of multiple primary melanoma (MPM) death. When some groups had a very high death rate or the reference group had a very low death rate in competing events, the results of Cox proportional hazard model may not be as accurate as the results obtained by fine-Gray regression model. Conclusion Early diagnosis and therapy, and prevention of tumor progression and metastases of primary melanoma patients are important measures to improve its prognosis and survival.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Bone Neoplasms
Cohort Studies
Sex Factors
Risk Factors
Internal medicine
medicine
Confidence Intervals
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
Melanoma
Aged
Neoplasm Staging
Proportional Hazards Models
Proportional hazards model
business.industry
Brain Neoplasms
Mortality rate
Hazard ratio
Liver Neoplasms
Age Factors
Hematology
General Medicine
Middle Aged
medicine.disease
Tumor progression
Cohort
T-stage
Regression Analysis
Female
business
Subjects
Details
- ISSN :
- 17696917
- Volume :
- 108
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Bulletin du cancer
- Accession number :
- edsair.doi.dedup.....31897bd7f081a72a0e05fc6d06edd742