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Diverse effects of c-src deficiency on molar tooth development and eruption in mice
- Source :
- Archives of Histology and Cytology. 70:63-78
- Publication Year :
- 2007
- Publisher :
- International Society of Histology & Cytology, 2007.
-
Abstract
- C-src deficiency is characterized by osteopetrosis due to impaired bone resorption by hypofunctional osteoclasts and the resultant failure of tooth eruption. In preliminary observations, we frequently encountered erupted molars in c-src deficient mice unlike in other osteopetrotic animals. Here we examine the effects of c-src deficiency on the development of molar teeth with an emphasis on the spatial relation of growing teeth with the surrounding bones. In c-src deficient mice, the magnitude of tooth impaction differed considerably among the types of molars; all maxillary 1st molars were totally impacted deep in the alveolar sockets, whereas most mandibular 1st molars fully erupted into oral cavity. Distribution of osteoclasts in the alveolar bone was identical among all types of molars, and electron microscopy revealed signs of bone resorbing activity in these osteoclasts despite the absence of a ruffled border. From early development, the alveolar space was much narrower in the upper molar tooth germs than in the lower ones in both wild type and homozygous animals, and particularly so in the upper 1st molars. Current observations thus indicate a significant contribution of "hypofunctional osteoclasts" in c-src deficient mice in molar tooth development except for the upper 1st molars, which appear to require highly functional osteoclasts to gain sufficient space for them to grow normally. Taken together, these findings on the seemingly tooth-type specific effects of c-src deficiency on the development and eruption of molar teeth in c-src deficient mice can be attributed to the given differential spatial relation of the respective tooth germs with the surrounding bones in the presence of hypofunctional osteoclasts.
- Subjects :
- Male
Molar
Heterozygote
Time Factors
Histology
Periodontal Ligament
Acid Phosphatase
Proto-Oncogene Proteins pp60(c-src)
Tooth eruption
Osteoclasts
Dentistry
Mandible
Biology
Bone resorption
Tooth Eruption
Mice
stomatognathic system
Maxilla
medicine
Tooth impaction
Animals
Periodontal fiber
Fluorescent Antibody Technique, Indirect
Dental alveolus
Mice, Knockout
Osteoblasts
Histocytochemistry
Tartrate-Resistant Acid Phosphatase
business.industry
Homozygote
Tooth Germ
Osteopetrosis
medicine.disease
Immunohistochemistry
Isoenzymes
Radiography
stomatognathic diseases
Female
business
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 13491717 and 09149465
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Archives of Histology and Cytology
- Accession number :
- edsair.doi.dedup.....3186ee06128028c77a3e68cda0e915b1