Back to Search
Start Over
Targeting Angiogenesis in Biliary Tract Cancers: An Open Option
- Source :
- International Journal of Molecular Sciences, Vol 18, Iss 2, p 418 (2017), International journal of molecular sciences, International Journal of Molecular Sciences
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Biliary tract cancers (BTCs) are characterized by a bad prognosis and the armamentarium of drugs for their treatment is very poor. Although the inflammatory status of biliary tract represents the first step in the cancerogenesis, the microenvironment also plays a key role in the pathogenesis of BTCs, promoting tumor angiogenesis, invasion and metastasis. Several molecules, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), are involved in the angiogenesis process and their expression on tumor samples has been explored as prognostic marker in both cholangiocarcinoma and gallbladder cancer. Recent studies evaluated the genomic landscape of BTCs and evidenced that aberrations in several genes enrolled in the pro-angiogenic signaling, such as FGF receptor-2 (FGFR-2), are characteristic of BTCs. New drugs targeting the signaling pathways involved in angiogenesis have been tested in preclinical studies both in vitro and in vivo with promising results. Moreover, several clinical studies tested monoclonal antibodies against VEGF and tyrosine kinase inhibitors targeting the VEGF and the MEK/ERK pathways. Herein, we evaluate both the pathogenic mechanisms of BTCs focused on angiogenesis and the preclinical and clinical data available regarding the use of new anti-angiogenic drugs in these malignancies.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
Vascular Endothelial Growth Factor A
Angiogenesis
Drug Evaluation, Preclinical
Tyrosine kinase inhibitor
Angiogenesis Inhibitors
Review
Fibroblast growth factor
Catalysi
Metastasis
Antineoplastic Agent
lcsh:Chemistry
chemistry.chemical_compound
angiogenesis
0302 clinical medicine
tyrosine kinase inhibitors
Molecular Targeted Therapy
lcsh:QH301-705.5
Spectroscopy
Clinical Trials as Topic
Monoclonal antibodie
Neovascularization, Pathologic
vascular endothelial growth factor
Computer Science Applications1707 Computer Vision and Pattern Recognition
General Medicine
Computer Science Applications
Vascular endothelial growth factor
Gene Expression Regulation, Neoplastic
Angiogenesi
Chemistry
Biliary Tract Neoplasms
Treatment Outcome
Biliary Tract Neoplasm
030220 oncology & carcinogenesis
monoclonal antibodies
Tyrosine kinase
Angiogenesis Inhibitor
Human
Signal Transduction
Protein Kinase Inhibitor
Antineoplastic Agents
biliary tract cancers
Biology
Models, Biological
Biliary tract cancers
Monoclonal antibodies
Tyrosine kinase inhibitors
Animals
Genetic Variation
Humans
Protein Kinase Inhibitors
Catalysis
Molecular Biology
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
03 medical and health sciences
In vivo
medicine
Gallbladder cancer
Animal
medicine.disease
030104 developmental biology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Immunology
Cancer research
Biliary tract cancer
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 18
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....3184c9fb39199ffcc61ec835079bd38d