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The effect of vitamin D supplementation on fibroblast growth factor‐23 in patients with chronic kidney disease: A systematic review and meta‐analysis
- Source :
- Phytotherapy Research. 35:5339-5351
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- This is a meta-analysis of randomized controlled trials (RCTs) investigating the effects of oral vitamin D supplementation on serum fibroblast growth factor-23 (FGF23) concentrations in patients with chronic kidney disease (CKD). Manuscripts were extracted from PubMed/MEDLINE, Scopus, and ISI Web of Science through February 2020. Subgroup analyses, sensitivity analysis, and meta-regression assessments were performed. A total of eight clinical trials with nine treatment arms were included in the final analysis. The pooled results showed no significant changes in circulating FGF23 following vitamin D supplementation compared to the control group (Standardized mean difference (SMD): 0.24; 95% confidence intervals (CIs): -0.03 to 0.50, p > 0.05). Subgroup analyses found that studies which had participants with a body mass index (BMI) higher than 25 kg/m2 , with an intervention duration shorter than 15 weeks, using phosphate binder medications, and trials that were on both patients with CKD undergoing hemodialysis and patients without hemodialysis treatment produced significant increases in FGF23 when concentration compared with the control group. This meta-analysis provides evidence that vitamin D supplementation does not have a significant effect on plasma FGF23 levels. However, further high-quality trials are required to identify the influence of oral vitamin D supplementation on FGF23 levels in patients with CKD.
- Subjects :
- Fibroblast growth factor 23
medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Gastroenterology
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Vitamin D and neurology
Humans
Renal Insufficiency, Chronic
Vitamin D
Pharmacology
0303 health sciences
business.industry
030302 biochemistry & molecular biology
Vitamins
medicine.disease
Phosphate binder
Fibroblast Growth Factors
Clinical trial
Fibroblast Growth Factor-23
030220 oncology & carcinogenesis
Dietary Supplements
Hemodialysis
business
Body mass index
Kidney disease
Subjects
Details
- ISSN :
- 10991573 and 0951418X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Phytotherapy Research
- Accession number :
- edsair.doi.dedup.....31822b531c169e48db4c52e6bc3a3837