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Plasma Circulating Cell-free DNA Integrity as a Promising Biomarker for Diagnosis and Surveillance in Patients with Hepatocellular Carcinoma

Plasma Circulating Cell-free DNA Integrity as a Promising Biomarker for Diagnosis and Surveillance in Patients with Hepatocellular Carcinoma

Authors :
Xiao-Wu Huang
Ya Cao
Jian Zhou
Xin Zhang
Ao Huang
Jia Fan
Shao-Lai Zhou
Xin-Rong Yang
Source :
Journal of Cancer
Publication Year :
2016
Publisher :
Ivyspring International Publisher, 2016.

Abstract

The clinical significance of circulating cell-free DNA (cfDNA) integrity as diagnostic and surveillance biomarker in hepatocellular carcinoma (HCC) was investigated and compared to that of alpha fetoprotein (AFP). Liver cancer patients had lower cfDNA integrity than those with benign diseases (P = 0.0167) and healthy individuals (P = 0.0025). Patients with HCC and non-HCC liver cancers (P = 0.7356), and patients with benign diseases and healthy individuals (P = 0.9138) had comparable cfDNA integrity respectively. cfDNA integrity increased after hepatectomy in cancer patients (P = 0.0003). The AUCs for detecting HCC by cfDNA integrity and AFP were 0.705 (P = 0.005) and 0.605 (P = 0.156), respectively. We found cfDNA integrity decreased in HCC patients and has the potential as promising biomarker for HCC diagnosis and treatment surveillance.

Details

ISSN :
18379664
Volume :
7
Database :
OpenAIRE
Journal :
Journal of Cancer
Accession number :
edsair.doi.dedup.....3175f395dda590669f32d2af4fb60f23
Full Text :
https://doi.org/10.7150/jca.15618