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Plasma Circulating Cell-free DNA Integrity as a Promising Biomarker for Diagnosis and Surveillance in Patients with Hepatocellular Carcinoma
Plasma Circulating Cell-free DNA Integrity as a Promising Biomarker for Diagnosis and Surveillance in Patients with Hepatocellular Carcinoma
- Source :
- Journal of Cancer
- Publication Year :
- 2016
- Publisher :
- Ivyspring International Publisher, 2016.
-
Abstract
- The clinical significance of circulating cell-free DNA (cfDNA) integrity as diagnostic and surveillance biomarker in hepatocellular carcinoma (HCC) was investigated and compared to that of alpha fetoprotein (AFP). Liver cancer patients had lower cfDNA integrity than those with benign diseases (P = 0.0167) and healthy individuals (P = 0.0025). Patients with HCC and non-HCC liver cancers (P = 0.7356), and patients with benign diseases and healthy individuals (P = 0.9138) had comparable cfDNA integrity respectively. cfDNA integrity increased after hepatectomy in cancer patients (P = 0.0003). The AUCs for detecting HCC by cfDNA integrity and AFP were 0.705 (P = 0.005) and 0.605 (P = 0.156), respectively. We found cfDNA integrity decreased in HCC patients and has the potential as promising biomarker for HCC diagnosis and treatment surveillance.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
hepatocellular carcinoma
medicine.medical_treatment
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Clinical significance
cfDNA
neoplasms
business.industry
Cancer
circulating cell-free DNA
medicine.disease
digestive system diseases
Circulating Cell-Free DNA
030104 developmental biology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
integrity
Biomarker (medicine)
Hepatectomy
business
Liver cancer
Alpha-fetoprotein
Research Paper
Subjects
Details
- ISSN :
- 18379664
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer
- Accession number :
- edsair.doi.dedup.....3175f395dda590669f32d2af4fb60f23
- Full Text :
- https://doi.org/10.7150/jca.15618