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Serum paraoxonase activity in patients with low glomerular filtration rates
- Source :
- Renal Failure. 32:562-565
- Publication Year :
- 2010
- Publisher :
- Informa UK Limited, 2010.
-
Abstract
- Epidemiological and experimental studies indicate that kidney disease is associated with increased oxidative stress. Our aim was to determine whether paraoxonase 1 (PON1) activity is altered in patients with moderately decreased glomerular filtration rates (GFRs) compared to healthy controls.Forty-eight patients showing relatively low GFRs upon renal scintigraphy with (99m)Tc-DTPA were compared to 40 age-matched healthy subjects. Serum PON1 activity was measured spectrophotometrically. Lipid hydroperoxide levels were measured via iodometric assay.The mean ages of the patient and control groups were 32.09 +/- 6.10 (range 23-50) and 31.30 +/- 5.30 (range 20-46) years, respectively. Serum PON1 (p= 0.949) and high-density lipoprotein (p= 0.473) levels did not differ between groups. Significant differences were detected between groups in terms of mean triglyceride (p= 0.009), very-low-density lipoprotein (p = 0.010), lipid hydroperoxide (p = 0.026), urea (p = 0.012), and creatinine (p = 0.001) levels, whereas total cholesterol (p = 0.520) and low-density lipoprotein (p = 0.161) were similar between groups. Mean GFR was significantly lower in the low GFR group compared to the control (p = 0.000).Our results indicate that PON1 activity and high-density lipoprotein levels may not be determining factors in premature vascular aging in patients with moderately decreased GFRs. Instead, some other undetermined factor(s) may be involved in modulating enzymatic activity.
- Subjects :
- Adult
Male
Lipid Peroxides
medicine.medical_specialty
Renal function
Critical Care and Intensive Care Medicine
medicine.disease_cause
Young Adult
chemistry.chemical_compound
Internal medicine
medicine
Humans
Renal Insufficiency
Triglyceride
biology
Aryldialkylphosphatase
business.industry
Paraoxonase
General Medicine
Middle Aged
medicine.disease
PON1
Oxidative Stress
Endocrinology
chemistry
Nephrology
Case-Control Studies
Urea
biology.protein
Female
Lipid Peroxidation
business
Oxidative stress
Glomerular Filtration Rate
Lipoprotein
Kidney disease
Subjects
Details
- ISSN :
- 15256049 and 0886022X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Renal Failure
- Accession number :
- edsair.doi.dedup.....3171cbdb74d3d7a50b7276b3e33e8f87