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A decomposable silica-based antibacterial coating for percutaneous titanium implant
- Source :
- International Journal of Nanomedicine
- Publication Year :
- 2017
- Publisher :
- Dove Press, 2017.
-
Abstract
- Jia Wang,1,* Guofeng Wu,2,* Xiangwei Liu,3,* Guanyang Sun,1 Dehua Li,3 Hongbo Wei3 1State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, 2Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 3State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally tothis work Abstract: Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this study, silica-gentamycin (SG) nanoparticles were successfully fabricated using an innovative one-pot solution. The nanoparticles were incorporated within a gelatin matrix and cross-linked on microarc-oxidized titanium. To characterize the SG nanoparticles, their particle size, zeta potential, surface morphology, in vitro drug release, and decomposition process were sequentially evaluated. The antibacterial properties against the gram-positive Staphylococcus aureus, including bacterial viability, antibacterial rate, and bacteria morphology, were analyzed using SG-loaded titanium specimens. Any possible influence of released gentamycin on the viability of human fibroblasts, which are the main component of soft tissues, was investigated. SG nanoparticles from the antibacterial titanium coating continuously released gentamycin and inhibited S. aureus growth. In vitro investigation showed that the obtained nanodelivery system has good biocompatibility. Therefore, this design can be further investigated as a method to prevent infection around percutaneous implants. Keywords: silica nanoparticles, microarc oxidation, gentamycin, control release, fibroblasts
- Subjects :
- Pharmaceutical Science
Nanoparticle
02 engineering and technology
silica nanoparticles
0302 clinical medicine
Coated Materials, Biocompatible
International Journal of Nanomedicine
Drug Discovery
Zeta potential
Original Research
Titanium
Cell Death
Prostheses and Implants
General Medicine
Adhesion
Staphylococcal Infections
Silicon Dioxide
021001 nanoscience & nanotechnology
Anti-Bacterial Agents
0210 nano-technology
Staphylococcus aureus
medicine.medical_specialty
Materials science
Biocompatibility
Cell Survival
Surface Properties
Biophysics
chemistry.chemical_element
Bioengineering
Microbial Sensitivity Tests
Biomaterials
03 medical and health sciences
gentamycin
medicine
Humans
Organic Chemistry
Biofilm
030206 dentistry
Fibroblasts
microarc oxidation
control release
Surgery
Drug Liberation
Chemical engineering
chemistry
Nanoparticles
Particle size
Gentamicins
Bacterial cellular morphologies
Subjects
Details
- Language :
- English
- ISSN :
- 11782013
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi.dedup.....316fc74595c13dfd42db942601bb8105