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B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells
- Source :
- Cells, Cells, Vol 10, Iss 1190, p 1190 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the production of autoantibodies, secretion of cytokines, and presentation of autoantigens to T cells. However, the mechanisms that underlie the development of autoreactive B cells are not well understood. Here, we review recent studies leveraging novel techniques to identify and characterize (auto)antigen-specific B cells. The insights gained from such studies pertaining to the mechanisms involved in the escape of tolerance checkpoints and the activation of autoreactive B cells are discussed. In addition, we briefly highlight potential therapeutic strategies to target and eliminate autoreactive B cells in autoimmune diseases.
- Subjects :
- 0301 basic medicine
QH301-705.5
Autoimmunity
Review
PERIPHERAL-BLOOD
Biology
Lymphocyte Activation
PRIMARY SJOGRENS-SYNDROME
03 medical and health sciences
0302 clinical medicine
N-GLYCOSYLATION SITES
Immune Tolerance
medicine
Animals
Humans
autoimmune diseases
Secretion
RITUXIMAB
Biology (General)
SYSTEMIC-LUPUS-ERYTHEMATOSUS
IMMUNOGLOBULIN VARIABLE REGION
B-cell activation
B-Lymphocytes
B cells
tolerance
DEPLETION THERAPY
Autoantibody
autoreactive B cells
General Medicine
Immune Checkpoint Proteins
Peripheral blood
RHEUMATOID-ARTHRITIS
Cell biology
Phenotype
030104 developmental biology
T-CELLS
AUTOANTIBODIES
Rituximab
Immunoglobulin Variable Region
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 20734409
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....3167bc74e231d913d313a4c43bac6222