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Age-dependent atrial remodeling induced by recombinant human interleukin-11: implications for atrial flutter/fibrillation
- Source :
- Journal of cardiovascular pharmacology. 39(3)
- Publication Year :
- 2002
-
Abstract
- Recombinant human interleukin-11 (rhIL-11) has been used to alleviate side effects caused by chemotherapy in patients with neoplastic diseases and as an experimental anti-inflammatory agent. Its use in elderly patients has been associated with increased frequency of atrial flutter/fibrillation (AF). The mechanism of the latter phenomenon was studied in a rat model in vivo. Adult and old Fischer 344 rats fed with either normal diet or sodium-restricted diets were treated with rhIL-11 or vehicle (control) (1 mg/kg/day, i.p., 7 days); cardiac electrophysiologic parameters and atrial dimensions were determined. In adult rats, rhIL-11 was without effect, and atrial pacing did not induce AF. In contrast, in old rats, rhIL-11 shortened atrial refractoriness and increased atrial dimensions. Also, atrial pacing induced AF in old rats treated with rhIL-11 more than in controls. These effects of rhIL-11 in old rats were reversed by sodium-restricted diet. It was concluded that rhIL-11 induces age-dependent atrial remodeling manifested by atrial stretch and reduced atrial refractoriness, which favor AF. Na retention is the most likely mechanism underlying this effect of rhIL-11.
- Subjects :
- Male
medicine.medical_specialty
Heart disease
Normal diet
Refractory period
Heart Ventricles
Blood Pressure
Electrocardiography
Internal medicine
Atrial Fibrillation
Medicine
Animals
cardiovascular diseases
Heart Atria
Pharmacology
Fibrillation
medicine.diagnostic_test
business.industry
P wave
Age Factors
Cardiac Pacing, Artificial
Atrial fibrillation
Organ Size
Diet, Sodium-Restricted
medicine.disease
Atrial Function
Interleukin-11
Rats, Inbred F344
Recombinant Proteins
Rats
Electrophysiology
Endocrinology
Atrial Flutter
cardiovascular system
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Atrial flutter
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 39
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular pharmacology
- Accession number :
- edsair.doi.dedup.....3154b86b4fb49aa96933149b48a1c21f