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Outcomes of autologous stem cell transplantation for multiple myeloma in Saudi Arabia
- Source :
- Annals of Saudi Medicine, Vol 41, Iss 4, Pp 198-205 (2021), Annals of Saudi Medicine
- Publication Year :
- 2021
- Publisher :
- King Faisal Specialist Hospital and Research Centre, 2021.
-
Abstract
- BACKGROUND: In 2015, multiple myeloma (MM) represented 1% of all cancers and about 5% of hematologic malignancies in Saudi cancer registry. We conducted this large study because only small pilot studies have examined MM outcomes after autologous stem-cell transplantation (ASCT). The standard therapy for eligible patients is induction chemotherapy followed by ASCT. OBJECTIVES: Determine the demographic characteristics of MM patients and the outcomes of ASCT. DESIGN: Retrospective. SETTING: Tumor registry database of major tertiary cancer care center in Riyadh. PATIENTS AND METHODS: We identified patients with newly diagnosed MM who underwent ASCT from October 1997 to March 2015. MAIN OUTCOME MEASURES: The demographic characteristics of MM patients and the outcomes of ASCT in the form of response evaluation, progression-free survival (PFS) and overall survival (OS). SAMPLE SIZE: 169 patients with newly diagnosed MM. RESULTS: The median age at diagnosis was 51 years (range 23–69) and 100 (59.2%) were male. The most common immunoglobulin (Ig) subtype was IgG-kappa (80 patients; 47.6%). Most patients presented with advanced ISS stage III (75 patients; 47.5%). The cytogenetic analysis was documented in only 87 patients (51.4%); about half (48.3%) had normal cytogenetics by fluorescence in situ hybridization. Deletion 13 was present in 18.4% of patients. In post-induction therapy, 84 patients (50%) achieved a complete response, which increased to 78.1% (132 patients) after ASCT. The median PFS and OS post-transplantation were 30 and 202 months, respectively. Only one patient ( CONCLUSIONS: Our transplant eligible MM patients tend to be younger with a higher OS and a low ASCT-related mortality ( LIMITATIONS: Usual limitations of a retrospective analysis using registry-level data; no data on quality of life. CONFLICTS OF INTEREST: None.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Saudi Arabia
Transplantation, Autologous
Disease-Free Survival
Young Adult
Autologous stem-cell transplantation
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
In Situ Hybridization, Fluorescence
Multiple myeloma
Aged
Retrospective Studies
business.industry
Hematopoietic Stem Cell Transplantation
General Medicine
Middle Aged
medicine.disease
Cancer registry
Treatment Outcome
Quality of Life
Large study
Medicine
Original Article
Multiple Myeloma
business
Subjects
Details
- ISSN :
- 09754466 and 02564947
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Annals of Saudi Medicine
- Accession number :
- edsair.doi.dedup.....314cb4ad8e427a98deb04170554da9f1