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Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp3)–H bonds
- Source :
- Chemical Science. 6:4973-4977
- Publication Year :
- 2015
- Publisher :
- Royal Society of Chemistry (RSC), 2015.
-
Abstract
- The authors thank the ERC (Advanced Researcher award-FUNCAT), the EPSRC (grant no EP/J011053/1) and King Saud University for funding. SPN is a Royal Society Wolfson Research Merit Award holder. The first nickel catalyzed deprotonative cross coupling between C(sp3)-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds. Publisher PDF
- Subjects :
- 010405 organic chemistry
Aryl
NDAS
chemistry.chemical_element
General Chemistry
QD Chemistry
010402 general chemistry
01 natural sciences
Medicinal chemistry
Coupling reaction
0104 chemical sciences
Catalysis
Metal
Nickel
chemistry.chemical_compound
chemistry
visual_art
visual_art.visual_art_medium
Organic chemistry
Moiety
QD
Amine gas treating
Palladium
Subjects
Details
- ISSN :
- 20416539 and 20416520
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.doi.dedup.....3138a08676947d33ffee17d9d86d3c5c