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Meroterpenoids from a Tropical Dysidea sp. Sponge

Authors :
Hyi-Seung Lee
Eunji Cho
Yeon-Ju Lee
Chung J. Sim
Jongheon Shin
Jung-Kyun Woo
Chang-Kwon Kim
Dong-Chan Oh
Ki-Bong Oh
Seong-Hwan Kim
Source :
Journal of natural products. 78(11)
Publication Year :
2015

Abstract

Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 4-6 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na(+)/K(+)-ATPase.

Details

ISSN :
15206025
Volume :
78
Issue :
11
Database :
OpenAIRE
Journal :
Journal of natural products
Accession number :
edsair.doi.dedup.....3130d2d342cc538ace6b4d268beb974c