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Meroterpenoids from a Tropical Dysidea sp. Sponge
- Source :
- Journal of natural products. 78(11)
- Publication Year :
- 2015
-
Abstract
- Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 4-6 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na(+)/K(+)-ATPase.
- Subjects :
- Stereochemistry
Pharmaceutical Science
Sesquiterpene
Analytical Chemistry
Terpene
chemistry.chemical_compound
Drug Discovery
Dysidea
Molecule
Animals
Humans
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
biology
Hydroquinone
Molecular Structure
Cytotoxins
Terpenes
Organic Chemistry
biology.organism_classification
Quinone
Sponge
Complementary and alternative medicine
chemistry
Molecular Medicine
Sodium-Potassium-Exchanging ATPase
K562 Cells
Two-dimensional nuclear magnetic resonance spectroscopy
Sesquiterpenes
Derivative (chemistry)
Micronesia
Subjects
Details
- ISSN :
- 15206025
- Volume :
- 78
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....3130d2d342cc538ace6b4d268beb974c