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Hyaluronic acid and platelet-rich plasma, a new therapeutic alternative for scleroderma patients: a prospective open-label study
- Source :
- Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-8 (2019), Arthritis Research & Therapy
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Systemic sclerosis is a systemic connective tissue disease characterized by endothelium damage, fibrosis, and subsequent atrophy of the skin. Perioral fibrosis produces a characteristic microstomia together with microcheilia, both of which cause severe difficulties and affects patients’ daily life, such as eating and oral hygiene. Since there are no effective and specific therapies, we have aimed at evaluating the response to filler injections of hyaluronic acid together with platelet-rich plasma. Methods Ten female patients aged between 18 and 70 were included in this study. Each patient was treated with three filler injections of hyaluronic acid and platelet-rich plasma at an interval of 15 to 20 days. Follow-up check-ups were recorded 1, 3, and 24 months after the end of the treatment. During the therapy and the subsequent follow-up, we evaluated the mouth’s opening, freedom of movement of the lips, and skin elasticity. Results After the treatment, patients had achieved good results already after the first injection and the improvement was maintained in the following months, up to 2 years. In particular, 8 (80%) patients showed a greater mouth’s opening and increased upper lip’s thickness during 1-month follow-up and maintained these results after 2 years (maximum mouth’s opening T0 47.61; T3 49.23; T4 48.60 p p p p p Conclusions Our study demonstrates that filler injections of hyaluronic acid and platelet-rich plasma represent an efficient local therapeutic alternative for patients affected by scleroderma. The treatment has significantly improved patients’ quality of living.
- Subjects :
- Adult
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Hyaluronic acid
Microcheilia
Gastroenterology
Systemic sclerosi
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Atrophy
Platelet-rich plasma
Fibrosis
Internal medicine
medicine
Humans
Prospective Studies
Systemic sclerosis
Therapy
Skin
030203 arthritis & rheumatology
Scleroderma, Systemic
Viscosupplements
Microstomia
business.industry
Middle Aged
medicine.disease
Connective tissue disease
Elasticity
Lip
Rheumatology
Settore MED/16 - Reumatologia
Treatment Outcome
chemistry
Quality of Life
Female
lcsh:RC925-935
business
Research Article
Subjects
Details
- ISSN :
- 14786362
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Arthritis Research & Therapy
- Accession number :
- edsair.doi.dedup.....3130c02406172d6484847de3af8ed912