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Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairment
- Source :
- Brain, Behavior, and Immunity. 26:904-910
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- The development of cognitive impairment in sepsis is associated with neurotoxic effects caused by oxidative stress. We have assessed the effects of acute and extended administration of guanosine (GUA) on brain oxidative stress parameters and cognitive impairment in rats submitted to sepsis by cecal ligation and perforation (CLP). To achieve this goal, male Wistar rats underwent either sham operation or CLP with GUA. Rats subjected to CLP were treated with intraperitoneal injection of GUA (8mg/kg after CLP) or vehicle. Twelve and 24h after CLP, the rats were sacrificed, and samples from brain (hippocampus, striatum, cerebellum, prefrontal cortex and cortex) were obtained and assayed for thiobarbituric acid reactive species (TBARS) formation and protein carbonyls. On the 10th day, another group of rats was submitted to the behavioral tasks. GUA administration reduced TBARS and carbonyl levels in some brain regions between 12 and 24h after CLP, and ameliorated cognitive impairment evaluated 10days after CLP. Our data provide the first experimental demonstration that GUA was able to reduce the consequences of CLP-induced sepsis in rats, by decreasing oxidative stress parameters in the brain and recovering the memory impairment.
- Subjects :
- Male
medicine.medical_specialty
Thiobarbituric acid
animal diseases
medicine.medical_treatment
Immunology
Perforation (oil well)
Intraperitoneal injection
Hippocampus
Striatum
medicine.disease_cause
Thiobarbituric Acid Reactive Substances
Protein Carbonylation
Sepsis
Behavioral Neuroscience
chemistry.chemical_compound
Memory
Internal medicine
Avoidance Learning
TBARS
Animals
Medicine
Rats, Wistar
Habituation, Psychophysiologic
Cecum
Ligation
Swimming
Guanosine
Endocrine and Autonomic Systems
business.industry
Brain
Recognition, Psychology
bacterial infections and mycoses
medicine.disease
Rats
Oxidative Stress
stomatognathic diseases
Cognitive impairment
Neuroprotective Agents
Endocrinology
chemistry
Anesthesia
Cognition Disorders
business
Oxidative stress
Subjects
Details
- ISSN :
- 08891591
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Brain, Behavior, and Immunity
- Accession number :
- edsair.doi.dedup.....31224a64798a7abeee2128da27d68ef3