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Reperfusion with nifedipine: improved functional recovery after cold cardioplegic arrest
Reperfusion with nifedipine: improved functional recovery after cold cardioplegic arrest
- Source :
- European Journal of Cardio-Thoracic Surgery. 2:360-363
- Publication Year :
- 1988
- Publisher :
- Oxford University Press (OUP), 1988.
-
Abstract
- Nifedipine, an antagonist of myocardial calcium uptake, given after a period of a cold, cardioplegic arrest (150 min, 18 degrees C, St Thomas' cardioplegic solution) improved contractile recovery of the isolated working rat heart model of cardiopulmonary bypass. The hearts were reperfused with various concentrations of nifedipine in Krebs-Henseleit buffer (37 degrees C, 100 cm H2O) and their functional recoveries were compared with the control series reperfused without nifedipine. A bell-shaped dose/response curve was produced by the drug, and optimal protection observed with 0.1 mumol/l of nifedipine which improved the post-ischaemic recovery of the aortic flow from 56.8% +/- 3.7% to 80.1% +/- 3.2% (P less than 0.001). The importance of careful dose adjustment is stressed since it was noted that higher concentrations inhibit both functional and metabolic performance. This study supports the hypothesis that at the end of a cold cardioplegic arrest there are still reversibly injured cells which could restore their function if the cellular ingress of Ca++ during reperfusion is reduced by nifedipine.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Nifedipine
Ischemia
Myocardial Reperfusion
Myocardial Reperfusion Injury
Pilot Projects
In Vitro Techniques
law.invention
law
Dose adjustment
Coronary Circulation
Internal medicine
Cardiopulmonary bypass
medicine
Animals
Myocardial calcium
Cardioplegic Solutions
Creatine Kinase
Dose-Response Relationship, Drug
business.industry
Myocardium
Antagonist
Heart
Rats, Inbred Strains
General Medicine
Aortic flow
medicine.disease
Functional recovery
Rats
Cold Temperature
Anesthesia
Cardiology
Surgery
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 10107940
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- European Journal of Cardio-Thoracic Surgery
- Accession number :
- edsair.doi.dedup.....311eb42074047c5bcdce25e2a5f68f02
- Full Text :
- https://doi.org/10.1016/1010-7940(88)90013-9